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Examples of scientific studies suggesting links between artificial sweeteners and weight gain include: A 2010 Yale Journal of Biology and Medicine review of the literature on artificial sweeteners concludes that, research studies suggest that artificial sweeteners may contribute to weight gain. A 2013 Trends in Endocrinology and Metabolism review article finds accumulating evidence suggests that frequent consumers of these sugar substitutes may also be at increased risk of excessive weight gain, metabolic syndrome, type 2 diabetes, and cardiovascular disease, and that frequent consumption of high-intensity sweeteners may have the counterintuitive effect of inducing metabolic derangements. A 2015 study of older adults in the Journal of the American Geriatrics Society found In a striking dose-response relationship, that increasing DSI [diet soda intake] was associated with escalating abdominal obesity A 2014 study published in Nature found that consumption of commonly used NAS [non-caloric artificial sweetener] formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota.our results link NAS consumption, dysbiosis and metabolic abnormalities.Our findings suggest that NAS may have directly contributed to enhancing the exact epidemic that they themselves were intended to fight. Cokes claims that its artificially sweetened sodas treat obesity are probably false, Ruskin said

Lancet Diab Endocrinol 6(3):237248 Ethics declarations Disclosures Dr